| Name | Status | Launch Service Provider | Rocket | Mission | Net | Pad |
|---|---|---|---|---|---|---|
| Atlas LV-3A | Samos 2 | Success | United States Air Force | Atlas Agena B | — | 01/31/1961 8:21 p.m. | Space Launch Complex 3W |
| Molniya 8K78 | Venera-1VA 1 | Failure | Strategic Missile Troops | Molniya 8K78 | — | 02/04/1961 1:18 a.m. | 1/5 |
| Molniya 8K78 | Venera-1VA 2 | Success | Strategic Missile Troops | Molniya 8K78 | — | 02/12/1961 12:43 a.m. | 1/5 |
| Scout X-1 | Explorer 9 | Success | National Aeronautics and Space Administration | Scout X-1 | — | 02/16/1961 1:05 p.m. | Launch Area 3 |
| Thor DM-21 Agena-B | Discoverer 20 | Success | United States Air Force | Thor DM-21 Agena-B | — | 02/17/1961 8:25 p.m. | Space Launch Complex 1W |
| Thor DM-21 Agena-B | Discoverer 21 (MIDAS RM-2) | Success | United States Air Force | Thor DM-21 Agena-B | — | 02/18/1961 10:57 p.m. | Space Launch Complex 1E |
| Thor DM-21 Ablestar | Transit 3B & LOFTI-1 | Partial Failure | United States Air Force | Thor DM-21 Ablestar | — | 02/22/1961 3:45 a.m. | Space Launch Complex 17B |
| Juno II | S-45 | Failure | Army Ballistic Missile Agency | Juno II | — | 02/25/1961 12:13 a.m. | Space Launch Complex 26B |
| Vostok-K | Sputnik 9 | Success | Strategic Missile Troops | Vostok | — | 03/09/1961 6:29 a.m. | 1/5 |
| Vostok-K | Sputnik 10 | Success | Strategic Missile Troops | Vostok | — | 03/25/1961 5:54 a.m. | 1/5 |
| Delta DM-19 | Explorer 10 | Success | United States Air Force | Delta DM-19 | — | 03/25/1961 3:17 p.m. | Space Launch Complex 17A |
| Thor DM-21 Agena-B | Discoverer 22 | Failure | United States Air Force | Thor DM-21 Agena-B | — | 03/30/1961 8:34 p.m. | Space Launch Complex 1W |
| Thor DM-21 Agena-B | Discoverer 23 | Success | United States Air Force | Thor DM-21 Agena-B | — | 04/08/1961 7:21 p.m. | Space Launch Complex 1E |
| Vostok-K | Vostok 1 | Success | Soviet Space Program | Vostok | Vostok 1 | 04/12/1961 6:07 a.m. | 1/5 |
| Atlas LV-3B | Mercury-Atlas 3 | Failure | National Aeronautics and Space Administration | Atlas | — | 04/25/1961 4:15 p.m. | Space Launch Complex 14 |
| Juno II | Explorer 11 | Success | Army Ballistic Missile Agency | Juno II | — | 04/27/1961 2:16 p.m. | Space Launch Complex 26B |
| Redstone MRLV | Mercury-Redstone 3 | Success | National Aeronautics and Space Administration | Redstone | Mercury-Redstone 3 | 05/05/1961 2:34 p.m. | Cape Canaveral Air Force Station Launch Complex 5 |
| Juno II | S-45A | Failure | Army Ballistic Missile Agency | Juno II | — | 05/24/1961 7:48 p.m. | Space Launch Complex 26B |
| Thor DM-21 Agena-B | Discoverer 24 | Failure | United States Air Force | Thor DM-21 Agena-B | — | 06/08/1961 9:16 p.m. | Space Launch Complex 1W |
| Thor DM-21 Agena-B | Discoverer 25 | Success | United States Air Force | Thor DM-21 Agena-B | — | 06/16/1961 11:02 p.m. | Space Launch Complex 2E |
| Thor DM-21 Ablestar | Transit 4A & Injun-1 & Solrad 3 | Success | United States Air Force | Thor DM-21 Ablestar | — | 06/29/1961 4:23 a.m. | Space Launch Complex 17B |
| Scout X-1 | S-55 | Failure | National Aeronautics and Space Administration | Scout X-1 | — | 06/30/1961 5:09 p.m. | Launch Area 3 |
| Thor DM-21 Agena-B | Discoverer 26 | Success | United States Air Force | Thor DM-21 Agena-B | — | 07/07/1961 11:29 p.m. | Space Launch Complex 1E |
| Delta DM-19 | Tiros-3 | Success | United States Air Force | Delta DM-19 | — | 07/12/1961 10:25 a.m. | Space Launch Complex 17A |
| Atlas LV-3A | MIDAS 3 | Success | United States Air Force | Atlas Agena B | — | 07/12/1961 3:11 p.m. | Space Launch Complex 3E |
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